Of the 749 patients with infections, meningitis was seen in 233 (31%) cases
Symptoms such as fever, headache, stiff neck, vomiting and change in consciousness occur inconsistently
Keywords: Infection, intrathecal baclofen therapy, meningitis, sepsis, Streptococcus dysgalactiae Go to: Introduction The aim of this retrospective study was to describe signs, symptoms, and clinical outcomes of individuals undergoing intrathecal baclofen (ITB) therapy who experienced pump-related Gram-negative infections including meningitis
It may be due to catheter contamination or more ominously actual intrareservoir infection
One of the major complications is hardware infection, which generally requires urgent removal of the pump and the intrathecal catheter, with the risk of severe baclofen withdrawal
The entire pump system was removed and the patient was treated successfully with a prolonged regimen of antibiotics
This is hypothesized to be due to poor wound healing, a higher percentage of gastrostomy tubes While pump-site infection rates have been reported to be approximately 1%, 5 there are no previous reports of baclofen pump infection caused by Escherichia coli
The infection was eradicated and baclofen therapy was continued uninterrupted
Furthermore, the presence of an intrathecal baclofen pump The Cerebral Palsy Research Network (CPRN) is preparing to roll out its first quality improvement (QI) protocol to reduce infections from the implantation of an intrathecal baclofen (ITB) pump
Due to bacterial biofilm formation, the optimal treatment strategy is usually for removal of the pump, followed by systemic antibiotics for treatment of local and CNS infection
The most common types of complications seen with ITB are catheter-related, involving infections (usually Staphylococcus aureus) at a rate of 1% to 5% within the first 6 weeks; a 5% to 15% rate of A 13-year-old female experienced a recurrence of baclofen pump-related central nervous system (CNS) infection caused by Achromobacter, despite absence of retained foreign material
77%, respectively; 3) meningitis, localized abscess formation, and osteomyelitis occurred in Introduction
Some complications that you may experience with the implant surgery include infection, meningitis (infection of the lining of the brain and central nervous system), spinal fluid leak, paralysis, headache, swelling, bleeding, and bruising
Gablofen ® (baclofen injection) is a gamma-aminobutyric acid (GABA) ergic agonist indicated for use in the management of severe spasticity of cerebral or spinal origin in adult and pediatric patients age 4 years and above
Background: Children with cerebral palsy (CP) and spasticity are often managed with intrathecal baclofen treatment (ITB)
This case of a patient with recurrent Staphylococcus aureus pump site empyema and meningitis leading to status dystonicus is described, who was successfully managed with A total of 571 baclofen pump surgeries were performed with 45 total infections
eligible patients undergo surgery to implant the pump which will administer the drug
Thousands of baclofen pumps have been implanted in the Meningitis is an infection and inflammation of the fluid and membranes surrounding the brain and spinal cord
concentration that should be used depends upon the total daily dose required as well as the delivery rate of the pump
Methods: Patients who had an initial ITB device implanted at our center were followed to determine the proportion of patients with infectious and noninfectious complications, identify risk factors for infection and describe ITB patients have an increased risk of meningitis after pump implantation
Intrathecal drug delivery device infection with Mycobacterium fortuitum has not been reported previously
Yaksh and colleagues (1,2) examined its efficacy after intrathecal use in the early 1980s
One of the major complications is hardware infection which generally requires urgent removal of the pump and the Baclofen pump pocket infection with a variety of Gram (-) and Gram (+) organisms, although rare, may be devastating
A neurosurgeon or a pain management physician performs this procedure
Due to bacterial biofilm formation, the optimal treatment strategy is usually for removal of the pump, followed by systemic antibiotics for treatment of local and CNS infection
Bernard L, Bussel B
Oral baclofen replacement with Intrathecal baclofen pump associated central nervous system (CNS) infection and meningitis is a rare but serious complication and may have dire consequences
He had no meningism and no obvious source of infection
Intrathecal Baclofen Pump Infection With Meningitis: Effective Treatment by Radical Debridement and Intrareservoir Baclofen–Vancomycin Co-Infusion Neuromodulation:
One of the major complications is hardware infection, which generally
Baclofen pump infections range from superficial to deep tissue infections and can cause meningitis given the connection to the intrathecal space
We report a case of an implanted baclofen pump infection and associated mycobacterium meningitis due to Mycobacterium fortuitum
Intrathecal baclofen pump-related infections can be serious and may cause superficial wound infection, deeper Baclofen pump infections range from superficial to deep tissue infections and can cause meningitis given the connection to the intrathecal space
Due to bacterial biofilm formation, the optimal treatment strategy is usually for removal of the pump, followed by systemic antibiotics for treatment of local and CNS infection
1 Fortu-nately infection is an unusual complication in baclofen pumps
Intra-reservoir gentamicin may be successful in treating pump infection with Pseudomonas aeruginosa without the need for pump removal
This is an effective and safe neurosurgical and pharmacological intervention associated with an improvement in patient quality of life
Gablofen ® (baclofen injection) is a gamma-aminobutyric acid (GABA) ergic agonist indicated for use in the management of severe spasticity of cerebral or spinal origin in adult and pediatric patients age 4 years and above
A 37-year-old man who presented with a baclofen pump infection and meningitis experienced acute onset of intrathecal baclofen withdrawal syndrome 12 hours after the pump had been surgically removed
Complications of ITB include infection at the pump or catheter site and late complications as well as revisions of the pump and catheter because of events such as battery expiration or implant malfunction
Due to bacterial biofilm formation, the optimal treatment strategy is usually for removal of the pump, followed by systemic antibiotics for treatment of local and CNS infection
Infection, including meningitis Headache with nausea and vomiting for several days following the lumbar puncture - 7 - Physical Medicine and Rehabilitation Meningitis
concentration that should be used depends upon the total daily dose required as well as the delivery rate of the pump
Patients with secondary spasticity or dystonia were more likely to have infections than patients with cerebral palsy (86% versus 14%; P < 0