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The kidneys excrete digoxin in direct proportion to the glomerular filtration rate; the liver metabolizes 16%
The half life of digoxin is 1
The half-life of digoxin is 36 to 48 hours in patients with normal renal function and 3
The elimination half-life of digoxin is long
were 1 to 2 mcg/L and probably today doses of approximately one-half would be more common in patients with heart failure (see Therapeutic Plasma Concentrations, this
The terminal elimination half-life of digoxin in patients with normal renal function is 30 to 40 h
3 days
) The half-life time is long (33-44h) meaning there is a low risk for digoxin toxicity
E
Digoxin distributes very The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%)
The patient has edema
5 to 2 days
Digoxin has a narrow therapeutic index and chronic toxicity is more likely in the elderly and those with renal impairment
5-5
Kidway took her digoxin at 8:00am on a Monday then the medication would be 75% cleared around 8:00am on Thursday in an elderly woman because of the prolonged half-life, in a The plasma half life of digoxin is Que
5 days
This is because digoxin has a shorter half-life and is less likely to accumulate in the fetus or breast milk
The elimination half-life in normal subjects is 37 hours
The higher an animal is in the food chain, the higher the concentration of dioxins
Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can Detailed Digoxin dosage information for adults and children
Digoxin toxicity can occur even when the serum digoxin concentration is within the therapeutic range (between 0
It is primarily eliminated unchanged via the kidneys (15% is metabolized and excreted via the liver); its half-life (~23–39 hours in dogs, and extremely variable in cats) is strongly influenced by renal function