Feb 5, 2010 INTRODUCTION URGENT EVALUATION AND MANAGEMENT Triage of outpatients with acute kidney injury Identifying patients for emergency department
The severity of acute kidney injury has a significant effect on the diuretic response to furosemide; a good 'urinary response' may be considered as a 'proxy' for having some
This review summarises the
Furosemide is commonly prescribed to patients with AKI in ICU settings, despite a contradictory evidence on their effectiveness and safety
Early identification of patients at high risk for AKI
Its incidence has been reported to range
5 mg/kg depending on prior furosemide-exposure) to predict the development of AKIN
Acute Kidney Injury (AKI) is a common and serious complication that is associated with several adverse outcomes including death, need for renal replacement therapy At least half of an administered furosemide dose is excreted unchanged into the urine, a process that is prolonged in kidney failure (half-life of furosemide increases) Discussion
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Recent retrospective literature has highlighted the risk of acute kidney injury (AKI) worsening after diuretic administration
Patients: Thirty critically ill patients with acute kidney injury without preexisting renal
A pilot trial (the SPARK study) compared low-dose frusemide versus placebo in patients with early AKI and found no difference in the rate of worsening AKI or need Ho KM, Power BM (2010) Benefits and risks of furosemide in acute kidney injury
However, this assumption is imprecise – the concept needs to be operationalized and validated
Patients were excluded from the study for the following reasons: history of allergies to furosemide, acute kidney injury before enrolment, other causes of heart failure including acute decompensated chronic heart failure and chronic heart failure requiring medications' dose‐adjustments, renal replacement therapy prior to hospitalization or Acute kidney injury (AKI) is an intricate clinical syndrome defined by a sudden decrease of kidney function, Furthermore, furosemide dosage had different timing and dosage in both studies
Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017: expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine
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In evaluating the dose-dependent effect of furosemide on the outcomes of AKI Purpose: Furosemide, a frequently prescribed diuretic for managing congestive heart failure and edema, remains a topic of debate regarding its potential risk of inducing acute kidney injury (AKI) in patients
This diuretic approach appeared to be similarly effective and safe in patients with preserved LVEF