The most common side effects with Harvoni (which may affect more than 1 in 10 people) are tiredness and headache
Foster Side effects Interactions FAQ What is Harvoni? Harvoni contains a combination of ledipasvir and sofosbuvir
Ledipasvir and sofosbuvir both belong to a class of medications known as anti-virals
There are 306 drugs known to interact with lovastatin, along with 6 disease interactions, and 2 alcohol/food interactions
When co-administered with Harvoni, a reduced dose of statins should be considered and careful monitoring for statin adverse reactions should be undertaken (see section 4
This is a total daily dose of 300 mg of glecaprevir and 120 mg of pibrentasvir Statins are commonly prescribed medications for lowering cholesterol
John's wort can make these statins less Additional Information for Patients
These classifications are only a guideline
Moderate Drug interactions can differ with various statins, including Crestor (rosuvastatin), Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin), or Zocor (simvastatin)
When co-administered with Harvoni, a reduced dose of statins should be considered and careful monitoring for statin adverse reactions should be undertaken (see section 4
The relevance of a particular drug interaction to a specific individual is difficult to determine
In the package of harvoni was an information sheet about side effects and what caught my eye was that it mentioned that blood pressure medication, namely metroprolol could cause unusually low blood pressure when mixed with harvoni
Additionally, Mavyret is not recommended concurrently with atorvastatin, lovastatin, and simvastatin due to increased statin concentration and increased risk of myopathy
Avoid combinations; the risk of the interaction outweighs the benefit
Harvoni is available as tablets and as granules in sachets
(Harvoni only) and the combination drugs Atripla (Zepatier only), Evotaz (Mavyret only), Reyataz (Mavyret only), Prezcobix (Zepatier only), and Symtuza Treatment with statins can be used in those with chronic, stable hepatitis C with elevated cardiac risk or a previous cardiac event
Harvoni may also be used with the medication ribavirin to treat people with HCV and cirrhosis
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Harvoni moderately interacts with Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis)
The most common side effects reported with this drug were fatigue, headache, asthenia, and nausea
The relevance of a particular drug interaction to a specific individual is difficult to determine
The relevance of a particular drug interaction to a specific individual is difficult to determine
Epclusa and Harvoni belong to the same class of medications, so they have similar effects in the body
blood dyscrasias
The recommended dosage of HARVONI in adults with genotype 1, 4, 5, or 6 HCV is one tablet (90 mg ledipasvir and 400 mg sofosbuvir) taken orally once daily with or without food [see CLINICAL PHARMACOLOGY]
Major: Highly clinically significant
For any interactions uncovered, the culprit drug pair is provided alongside a relative severity level: minor
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine
(Classes are drugs grouped together by how they work
ledipasvir/sofosbuvir will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter
Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems
apalutamide (Erleada) 3
While the mainstay of treatment for hyperlipidemia is use of a statin, the management of patients with hepatitis
HCV patients are mostly in the need for polypharmacy, particularly the comedication of DAAs and cardiovascular drugs such as statins
Undesirable Effects Pharmacological Properties Interactions Posology Contraindications Excipients Storage precautions Print SmPC information Expand
Drug‐Drug Interactions May Require Statin Dose Adjustments or Discontinuation
Mild side effects Serious side effects FAQs Specifics Precautions Talk with your doctor Harvoni (ledipasvir/sofosbuvir) is a brand-name drug that’s
Most common adverse reactions (≥10%, all grades) were fatigue, headache, and asthenia
, afatinib, lapatinib) warfarin; If
Clinically important drugs that interact with statins and increase the risk of adverse effects include fibrates, diltiazem, verapamil, and amiodarone
Each one blocks a protein that the hep C virus needs in order to grow: Ledipasvir blocks a protein called NS5A
This is a total daily dose of 300 mg of glecaprevir and 120 mg of pibrentasvir Griseofulvin Interactions
Harvoni may also be used with the medication ribavirin to treat people with HCV and cirrhosis
Major: Highly clinically significant
Moderate 3
If Harvoni has been prescribed for your child, please note that all the information in this leaflet is applicable to your child (in this case please read “your child” instead of “you”)
4)
Moderate Lovastatin Interactions
Examples include atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor, FloLipid)
It must also not be used together with the following medicines which can reduce the effects of Harvoni: rifampicin and rifabutin (antibiotics); Side effects and risks
This article summarises the most Epclusa (sofosbuvir and velpatasvir) is a prescription drug used to treat hepatitis C
Ledipasvir and sofosbuvir both belong to a class of medications known as anti-virals