Harvoni statin interaction

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  • Avoid combinations; the risk of the interaction outweighs the benefit
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  • Grapefruit juice also interacts with atorvastatin
  • 4)
  • Harvoni can be used in several special populations
  • Avoid combinations; the risk of the interaction outweighs the benefit
  • Major: Highly clinically significant
  • Major: Highly clinically significant
  • Other drugs that have the same active ingredients (e
  • Avoid combinations; the risk of the interaction outweighs the benefit
  • Educational Videos
  • How Does
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  • These classifications are only a guideline
  • These classifications are only a guideline
  • Harvoni [package insert]
  • Major: Highly clinically significant
  • Major: Highly clinically significant
  • The most common side effects with Harvoni (which may affect more than 1 in 10 people) are tiredness and headache

    Foster Side effects Interactions FAQ What is Harvoni? Harvoni contains a combination of ledipasvir and sofosbuvir

    Ledipasvir and sofosbuvir both belong to a class of medications known as anti-virals

    There are 306 drugs known to interact with lovastatin, along with 6 disease interactions, and 2 alcohol/food interactions

    When co-administered with Harvoni, a reduced dose of statins should be considered and careful monitoring for statin adverse reactions should be undertaken (see section 4

    This is a total daily dose of 300 mg of glecaprevir and 120 mg of pibrentasvir Statins are commonly prescribed medications for lowering cholesterol

    John's wort can make these statins less Additional Information for Patients

    These classifications are only a guideline

    Moderate Drug interactions can differ with various statins, including Crestor (rosuvastatin), Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin), or Zocor (simvastatin)

    When co-administered with Harvoni, a reduced dose of statins should be considered and careful monitoring for statin adverse reactions should be undertaken (see section 4

    The relevance of a particular drug interaction to a specific individual is difficult to determine

    In the package of harvoni was an information sheet about side effects and what caught my eye was that it mentioned that blood pressure medication, namely metroprolol could cause unusually low blood pressure when mixed with harvoni

    Additionally, Mavyret is not recommended concurrently with atorvastatin, lovastatin, and simvastatin due to increased statin concentration and increased risk of myopathy

    Avoid combinations; the risk of the interaction outweighs the benefit

    Harvoni is available as tablets and as granules in sachets

    (Harvoni only) and the combination drugs Atripla (Zepatier only), Evotaz (Mavyret only), Reyataz (Mavyret only), Prezcobix (Zepatier only), and Symtuza Treatment with statins can be used in those with chronic, stable hepatitis C with elevated cardiac risk or a previous cardiac event

    Harvoni may also be used with the medication ribavirin to treat people with HCV and cirrhosis

    3)]

    Harvoni moderately interacts with Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis)

    The most common side effects reported with this drug were fatigue, headache, asthenia, and nausea

    The relevance of a particular drug interaction to a specific individual is difficult to determine

    The relevance of a particular drug interaction to a specific individual is difficult to determine

    Epclusa and Harvoni belong to the same class of medications, so they have similar effects in the body

    blood dyscrasias

    The recommended dosage of HARVONI in adults with genotype 1, 4, 5, or 6 HCV is one tablet (90 mg ledipasvir and 400 mg sofosbuvir) taken orally once daily with or without food [see CLINICAL PHARMACOLOGY]

    Major: Highly clinically significant

    For any interactions uncovered, the culprit drug pair is provided alongside a relative severity level: minor

    If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine

    (Classes are drugs grouped together by how they work

    ledipasvir/sofosbuvir will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter

    Get medical help right away if you take amiodarone with HARVONI and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems

    apalutamide (Erleada) 3

    While the mainstay of treatment for hyperlipidemia is use of a statin, the management of patients with hepatitis

    HCV patients are mostly in the need for polypharmacy, particularly the comedication of DAAs and cardiovascular drugs such as statins

    Undesirable Effects Pharmacological Properties Interactions Posology Contraindications Excipients Storage precautions Print SmPC information Expand

    Drug‐Drug Interactions May Require Statin Dose Adjustments or Discontinuation

    Mild side effects Serious side effects FAQs Specifics Precautions Talk with your doctor Harvoni (ledipasvir/sofosbuvir) is a brand-name drug that’s

    Most common adverse reactions (≥10%, all grades) were fatigue, headache, and asthenia

    , afatinib, lapatinib) warfarin; If

    Clinically important drugs that interact with statins and increase the risk of adverse effects include fibrates, diltiazem, verapamil, and amiodarone

    Each one blocks a protein that the hep C virus needs in order to grow: Ledipasvir blocks a protein called NS5A

    This is a total daily dose of 300 mg of glecaprevir and 120 mg of pibrentasvir Griseofulvin Interactions

    Harvoni may also be used with the medication ribavirin to treat people with HCV and cirrhosis

    Major: Highly clinically significant

    Moderate 3

    If Harvoni has been prescribed for your child, please note that all the information in this leaflet is applicable to your child (in this case please read “your child” instead of “you”)

    4)

    Moderate Lovastatin Interactions

    Examples include atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor, FloLipid)

    It must also not be used together with the following medicines which can reduce the effects of Harvoni: rifampicin and rifabutin (antibiotics); Side effects and risks

    This article summarises the most Epclusa (sofosbuvir and velpatasvir) is a prescription drug used to treat hepatitis C

    Ledipasvir and sofosbuvir both belong to a class of medications known as anti-virals

    Major: Highly clinically significant

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  • Harvoni statin interaction
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