Although considered safe, digoxin has a narrow therapeutic window, and its proper dosing requires IV: 8 to 12 mcg/kg
0 to 4
0 µg/L
8 ng/mL, although others suggest that 1 ng/mL to 2 ng/mL is an appropriate therapeutic range
I take 25 mg metoprolol every other day
Side effects
Drawing levels:-Determine serum digoxin levels at least 6 to 8 hours after the last regardless of the route of administration in order to allow sufficient time for drug distribution
, medications
In our study, inappropriate serum digoxin measurement was found to be very high although only one of the appropriateness criteria was evaluated
How the Test is Performed
B Digoxin levels need to be monitored because digoxin is a drug that has a narrow safety range
The main purpose of this test is to determine the best dosage of digoxin and prevent side effects
interpretation of the digoxin level in digoxin intoxication
Ninety percent of nontoxic patients have levels ≤2
Blood glucose level of 82
Digoxin loading oral: 500-750mcg 2 doses 6 hours apart (max 1500mcg in 24 hours) Note: when converting from the oral to the IV formulation the dosage should be reduced by 33% to take account of the difference in Digoxin Toxicity
Dosing regimen for digoxin-specific antibody (Fab) fragments in patients with digoxin toxicity
Patients with CrCl less than 60 mL/min should receive adjusted weight-based doses to reduce the risk of toxicity (6-10 μg/kg instead of 8-12 μg/kg)
The toxicity increases as the serum drug levels increase above 2
Sudden cardiac death occurred twice as often in new digoxin users compared to matched controls Maintenance dose: 2
Your doctor will check your dose is right and you'll be asked to have blood tests
Digoxin is absorbed quickly from the gastrointestinal tract with a bioavailability of between 75% and 95%
The annual mean frequencies of monitoring SDC, serum potassium level and serum creatinine level and of recording electrocardiograms was 16
Digoxin Serum digoxin level, BMP Every 6 months Diuretics BMP Within the first month and every 6 months Fibrates CBC, LFTs Every 6 months Lithium Serum lithium level Every 3 months Narrow therapeutic window; increased monitoring with drug interactions Nitrofurantoin Serum creatinine Prior to initiation Do not use for CrCL <60ml/min (SOM) or It may be recommended that adult men with clinically stable heart failure and normal renal function be prescribed a daily digoxin dose of 0
5 to 7 hours, and steady state is achieved after 4 to 5 half lives
5% in 2018
It is also used for atrial fibrillation to reduce the ventricular rate
9 nanogram/mL
Evaluate patient carefully to determine the appropriate dose
4 Ask your healthcare provider what your test results mean for you
Comment
How often is a digoxin level drawn? Equilibration of serum and tissue levels occurs at approximately 6 to 8 hours