The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein
We reviewed many studies on the pharmacokinetics, drug design and toxicity of lithium based on recent relevant research from PubMed, Web of Science, Elsevier and Springer databases
Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood
Lithium is an element of the alkali-metal group with atomic number 3, atomic weight 6
Lithium remains a mainstay of treatment for bipolar disorder, especially for acute mania and maintenance treatment []
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Since the onset of action is slow (five to ten days), parenteral administration is of no advantage
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The mechanism of action is still controversial and may involve the calcium/1,4,5-phosphatidylinositol pathway
It is now increasingly apparent that the anticonvulsants carbamazepine and valproate also share components of this spectrum of efficacy in the affective disorders but, in The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1
Antimanic Agent
Lithium has been an enigmatic drug with multifaceted actions involving various neurotransmitters and intricate cell signalling cascades
Gen
The primary mechanism of lithium is the inhibition of thyroid hormone release by inhibiting the action of TSH on cAMP [4, 25, 26]
It is the first medications approved for the treatment of bipolar disorders