Acyclovir antiviral mode of action

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  • Jul 20, 1982 · Mechanism of action and selectivity of acyclovir
  • 4 μM against herpes simplex disease type 2 16 and 47
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  • An analysis of the action mechanism of known antiviral drugs concluded that they can increase the cell's resistance to a virus (interferons), suppress the virus adsorption in the

    Mechanism of Action

    Acyclovir elfectively inhibits in vitro replication of HSV-1, herpes simplex virus type 2 (HSV-2), and varicella zoster virus (VZV) and is currently used for clinical

    Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus DNA polymerase

    This inhibitory action is highly selective as the drug must be converted to the active form by a virus

    There are two main types of antiviral drugs: the first type prevents the penetration of the virus into the cell, the second type disrupts the replication of the viral

    This An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus

    Activity requires viral TK

    Acyclovir, 9- (2-hydroxyethoxymethyl)guanine, is an acyclic nucleoside analogue which has a high activity and selectivity for herpes viruses, particularly herpes simplex viruses types 1 and 2 and varicella zoster virus

    Antiviral Classification is a comprehensive review article that provides an overview of the different types of antiviral agents, their mechanisms of action, and their applications in various viral diseases

    Aoki, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (Eighth Edition), 2015 Spectrum

    DB00198

    This activity describes the indications, action, and contraindications for acyclovir as a valuable medication in treating HSV infections

    Boost the immune system, helping it fight off a viral infection

    DB00577

    Acyclovir Class: Acyclovir is an acyclic analogue of 2'-deoxyguanosine

    , 2008 )

    Like acyclovir, penciclovir is first monophosphorylated by viral TK, then further modified to the triphosphate form by cellular enzymes

    Pharmacology and mechanism of action

    However, resistance among some virus forms is possible because of changes in TK or in the DNA The mechanism of action of acyclovir involves highly selective inhibition of herpes virus DNA replication, via enhanced uptake in herpes virus-infected cells and phos-phorylation by viral thymidine kinase, and the substrate specificity of acyclovir triphosphate for viral, rather than cellular, DNA polymerase

    The antiviral drugs based on their common mechanisms of action can be of two types, that is, drugs targeting virus and drugs targeting host

    Acyclovir belongs to the family of medicines called antivirals, which are used to treat infections caused by viruses

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