Topiramate invention

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  • 6
  • 2 DOSAGE AND ADMINISTRATION 2
  • Epilepsy has remained a disease plagued by polypharmacy and the aforementioned adherence issues, which can result in breakthrough seizures, drug-drug Description for Topamax

    More specifically, the present invention provides a solid dosage formulation of topiramate intended primarily for use by pediatric patients, or for patients who have difficulty swallowing tablets

    2

    The recommended dosage of topiramate for migraine prevention is 100 mg/day (50 mg twice daily), which is less than the target anti-epileptic dose

    The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile

    Topiramate has some rare but serious side effects such as acidosis, which manifests in symptoms of confusion, abnormal breathing and/or heartbeat, and fatigue

    Topiramate Pill Images

    The formulations comprise a sustained-release component and an optional immediate-release component, the compositions of which can be selectively adjusted, respectively, to release the active ingredient along a pre-determined release profile

    The present invention provides enhanced immediate release formulations of topiramate, in which 80% of the active ingredient is released in the period of time of not more than 30 min

    5

    For example, topiramate prepared by process of the present invention is stable for more than 3 years In pediatric wards, topiramate is prescribed as an antiepileptic at non-licensed dosages

    3

    Topiramate in the highly pure form is understood here as meaning an active substance which contains at least 99% by weight of topiramate

    Filed: March 27, 2023

    Adults and adolescents (age 17 or older): The typical starting dose is 25 mg to 50 mg by mouth once daily

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