ABSTRACT: Necrotizing soft-tissue infections (NSTIs) are a type of serious bacterial infection that requires rapid recognition and intervention by physicians and
Vitamin D to Prevent Acute Respiratory Infections? Clindamycin Improves Outcomes in Necrotizing Fasciitis Due to Group A
Ampel, MD, reviewing Andreoni F et al
necrotizing soft tissue infections
Com" Mark Nguyen, PharmD, BCEMP
Diagnosis is supported by signs of systemic toxicity with toxic-shock-like symptoms, severe pain or pain out of proportion to physical findings, altered mental status, rapidly advancing infection, crepitus, hemorrhage, sloughing
Clindamycin resistance among β-hemolytic streptococcal NSTI has also been associated with increased amputation risk
10 Eighty-four patients met the criteria for invasive GAS disease, and IVIG was used in 14 patients, including eight with necrotizing fasciitis
Necrotizing fasciitis is an uncommon and life-threatening deep tissue infection
Although necrotizing fasciitis is most often associated with bacterial infections, zygomycosis is an uncommon cause
Necrotizing fasciitis (NF) is a skin and soft tissue infection condition that is rapidly progressive and leads to fulminant tissue necrosis and can be life-threatening if left untreated []
We hypothesized that discontinuing antibiotic agents after a short course is safe
Although some necrotizing infections may still be susceptible to penicillin, clindamycin is the treatment of choice Simultaneously, we started the empiric antibiotic therapy with Peperacilin-Tazobactam and Clindamycin
Mixed aerobic-anaerobic bacteria [Type I] Group A Streptococcus (GAS, S
Gall SA, Kohan AP, Ayers OM, et al
A red flag suggesting toxic shock is a patient with an unimpressive focus of infection (e
Polymicrobial NF mostly occurs in immunocompromised individuals
Alternatively, anaerobic and gram-negative bacteria can be treated with one drug that covers both
Gall SA, Kohan AP, Ayers OM, et al
Necrotizing fasciitis is a rapidly progressive inflammatory infection of the fascia, with secondary necrosis of the subcutaneous tissues