It is also used in other hematologic conditions- thrombocytopenia, polycythemia vera, sickle cell anemia
The laboratory results show cobalamin levels of 125 pg/mL
Hydroxyurea (mechanism, use, toxicity) -Mechanism: inhibits ribonucleotide reductase decreasing DNA Synthesis (S-phase specific)
Potassium 5
(dose-limiting toxicity) • Dermatological reactions - ulcerations - Eczema • Gastrointestinal toxicity Hydroxyurea (drioxial) 6 terms
It is also useful to increase fetal hemoglobin concentration, thus reducing the frequency of severe crisis and reducing the necessity for blood transfusions in patients with sickle cell anemia
It is also used in other hematologic conditions- thrombocytopenia, polycythemia vera, sickle cell anemia
we summarize recent findings regarding the impact of hydroxyurea on living organisms
It is also useful to increase fetal hemoglobin concentration, thus reducing the frequency of severe crisis and reducing the necessity for blood The decision about whether to take any medicine depends on balancing the likelihood of benefit against the risk of harm
A good continuous doctor-patient relationship and rapport must exist to ensure that potential toxicity is identified at its onset Hydroxyurea is an antimetabolite that is used in the treatment of cancer and to stimulate fetal hemoglobin production in sickle cell disease
13 Drug package inserts serve as the primary source of information used by the NIOSH Hazardous Drug Committee
It is used in the treatment of many myeloproliferative disorders (MD) such as chronic myeloid leukaemia, polycythemia vera or management of other Sickle cell anemia (SCA) is a severe, inherited hemoglobin disorder affecting 100,000 persons in the US and millions worldwide
Over the last 20 years a vast array of data has been accumulated on the efficacy of hydroxyurea (HU) in patients with Philadelphia-negative myeloproliferative disorders (MPD)
2 mEq/L, a nurse is assessing a client who has myasthenia a
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low hemoglobin levels low platelet count increased potassium levels Rationale low hemoglobin and platelet levels indicate toxicity Study with Quizlet and memorize flashcards containing terms like decongestants, tamoxifen (side effects), opioid (side effect and tx) and more
Interactions-Cytotoxic medications and antivirals can increase risk for toxicity
acetylcysteine
Which agent would the nurse expect to be given?, A client is receiving epoetin alfa for anemia
The patient is HIV-positive and has anemia related to zidovudine therapy
21 A similar approach was taken in the phase 3 BABY HUG trial, 11 which featured an initial fixed dose of 20 mg/kg/d that a
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The therapeutic effect of epoetin alfa is an increase in hematocrit levels, which can result in an increase in a client's blood pressure
Large ingestions frequently delay gastric emptying, and ingestions of enteric capsules may cause a Which laboratory test result would cause the nurse to question administration of hydroxyurea? Thrombocyte count of 8000/mm 3
Which nursing action is most appropriate for handling chemotherapeutic agents? Wear disposable gloves and protective clothing
Neutrophils 1,400/mm
Which of the following information regarding the adverse effects of fentanyl should the nurse plan to give to the client and family? The provider will prescribe naloxone at home for respiratory depression
Method We included original articles published in English from 1st Study with Quizlet and memorize flashcards containing terms like A 42-year-old female is interested in making dietary changes to reduce her risk of colon cancer
which of the following electrolyte values increases a clients risk for digoxin toxicity?, A nurse is caring for a client who has a new prescription for digoxin and takes multiple other medications
Epogen stimulates the production of red blood cells to treat anemia
Hemarthrosis into the joint cavities of a child with hemophilia is a clinical manifestation
Study with Quizlet and memorize flashcards containing terms like A nurse is reviewing the medical record of a client who has hypertension
Which diagnostic tests are utilized? Select all that apply
Signs and Symptoms of Magnesium Toxicity
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What is a priority teaching point included by the nurse to improve compliance and safety?, A patient presents at the clinic complaining of vaginal itching and a clear discharge
0 ng/mL for rate control in atrial fibrillation) will show toxic levels at above 2
Which of the following client statements should indicate to the nurse that the teaching is effective? - "I will have increased saliva production
Nursing/Client (Hydroxyurea) Nursing/Client -Administer with antiemetic -Monitor WBC
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In this review, we summarize recent findings regarding the impact of hydroxyurea on living organisms
Hydroxyurea is an antineoplastic agent used alone or in combination with other chemotherapeutic drugs or radiation in the treatment of resistant leukemias
The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center
An expert panel report evaluating the toxicity of hydroxyurea has led to recommendations that hydroxyurea is stopped in men and women who are trying to
Clinical experience now documents the safety and efficacy of hydroxyurea for SCA beyond 15 to 20 years of treatment; the remarkably consistent findings of improved
Hydroxyurea / toxicity* Myeloproliferative Disorders /
Study with Quizlet and memorize flashcards containing terms like What are some examples of other antineoplastics?, Bleomycin is used in the treatment of?, What are main side effects of bleomycin? and more
Study with Quizlet and memorize flashcards containing terms like A client is experiencing iron toxicity
A nurse has been assigned to a 43-year-old man who is to receive epoetin alfa therapy
The
21 A similar approach was taken in the phase 3 BABY HUG trial, 11 which featured an
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Embryo-fetal toxicity, avoid live vaccines, skin ulcers, macrocytosis Which of the following findings should the nurse monitor? Increased blood pressure
Salts of salicylic acid are rapidly absorbed intact from the gastrointestinal tract, with appreciable serum concentrations occurring within 30 minutes
Disconnect I
The bulletin said, "These findings are the results of data analyzed from the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH), which was a double-blind, placebo-controlled trial in
( 1 - 4) To determine process issues that may contribute to these barriers we sought to: 1) describe how providers monitor and adjust HU dosing in
This systematic review and meta-analysis aimed to evaluate the role of hydroxyurea in
A nurse is assessing a client who is taking amiodarone to treat atrial fibrillation
Signs of iron deficiency anemia include dyspnea, tachycardia, and pallor, as well as fatigue, listlessness, irritability, and headache
Chronic kidney disease slows the production of red blood cells causing anemia
Hydroxyurea is a potent inducer of fetal hemoglobin, and evidence over the past 25 years has documented its laboratory and clinical efficacy for both adults and children with SCA