Seroquel, whose generic name is quetiapine, is an antipsychotic medication
Phase I metabolism, with primary involvement of the cytochrome P450 (CYP) enzyme system, is reduced in function in cases of a liver disease, with certain enzymes such as CYP3A4 and CYP2C19 being affected earlier in the disease course and others being affected later (such as CYP2D6 and CYP1A2)
Quetiapine (Seroquel, Seroquel XR) is an atypical antipsychotic used to treat schizophrenia, bipolar disorder and depression
Quetiapine extended-release tablet is also used together with other antidepressants to treat major depressive disorder
Quetiapine oral tablet is a prescription drug used to treat bipolar disorder, schizophrenia, and depression
These may lead to falling, which can cause broken bones or other health problems
Constipation, drowsiness, upset stomach, tiredness, weight gain, blurred vision, or dry mouth may occur
However, if your doctor tells you to take it a certain way, take it as directed
Infection—fever, chills, cough, or sore throat
Constipation, drowsiness, upset stomach, tiredness, weight gain, blurred vision, or dry mouth may occur
Quetiapine (Seroquel) is an antipsychotic drug that Learn about quetiapine (Seroquel) usage and dosing
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
The risk may be greater in people who have had these thoughts or actions in the past
Day 4: 150 mg orally 2 times a day
The metabolism of quetiapine is mediated by the cytochrome P450 system, and CYP 3A4 and CYP 2D6 are the predominant enzymes involved in drug transformation
sweating
Stomach-related side effects
Your doctor may ask you to change your dose, depending on how well quetiapine works for you
It is also known by the trade names Atrolak, Biquelle, Seroquel, Tenprolide and Zaluron
Common side effects include dizziness, drowsiness, and weight gain
5%) in geriatric patients with dementia-related psychosis † [off-label] receiving atypical antipsychotic agents (e
g
Dosage range: 400-800 mg/day; not to exceed 800 mg/day
Quetiapine can increase the amount of sugar in your blood, and this can sometimes lead to diabetes
The possible involvement of P450 enzymes Learn about Quetiapine Fumarate: What it is used for, how to take Quetiapine Fumarate, serious side effects, food and drug interactions, forms, doses, safe storage, and FAQs
mild allergic reaction *
In vitro studies suggest that the cytochrome P-450 (CYP) 3A4 isoenzyme is involved in the metabolism of quetiapine to the inactive sulfoxide metabolite, which is the principal metabolite
• Concomitant use of strong CYP3A4 inducers: Increase quetiapine dose up to 5 fold when used in combination with a chronic treatment (more than 7-14 days) of potent CYP3A4 inducers (e
3) • Discontinuation of strong CYP3A4 inducers: Reduce quetiapine dose Quetiapine for Major Depressive Disorder: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines is a comprehensive book that summarizes the current evidence on the use of quetiapine, an atypical antipsychotic, for treating major depressive disorder
In this article we aimed to evaluate the effect of atypical antipsychotic drugs namely olanzapine
The metabolism of quetiapine is mediated by the cytochrome P450 system, and CYP 3A4 and CYP 2D6 are the predominant enzymes involved in drug
Quetiapine was considered to be a non-hepatotoxic drug except for a mild and transient asymptomatic elevation of liver enzymes prior to the first published report
Atypical antipsychotic drugs commonly cause asymptomatic increase in the liver enzymes and serum bilirubin levels
Seroquel use may cause elevated liver enzymes
Conclusion: The effect of lamotrigine in reducing quetiapine concentration is only
Seroquel is a brand (trade) name for quetiapine which may be used to calm and help diminish psychotic thoughts
The risk may be greater in people who have had these thoughts or actions in the past
Maintenance therapy usual dosage range: 400 to 800 mg/day; maximum dose: 800 mg/day
Quetiapine may increase the risk of death in older adults with mental health problems related to dementia
swollen glands
It’s possible to have sexual side effects, including erectile dysfunction, with quetiapine use
After Day 5: Further dose adjustments in may be made in increments of no greater than 100 mg/day
The most commonly reported hepatic adverse reaction is elevated liver enzymes
The most likely etiology in our patient’s case was quetiapine-induced liver injury
Doses may be lower for older people and people with liver problems
This includes information on what the medication is for, how to take it, possible side effects Heart rhythm problem (eg, congenital long QT interval) or
Trouble urinating, or history of—May increase risk for more serious side effects
Day 2: 200 mg/day PO divided q12hr
A frequency of elevated liver enzymes of 2% was reported, but only 1 case of severe DILI was reported
We describe a rare case of a patient who developed an acute liver injury after initiation of therapy with quetiapine, but after conservative management and a trial of steroids, has fully recovered
Quetiapine undergoes an extensive liver biotransformation, involving cytochromes P450 conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
Increased Mortality in Geriatric Patients Substantially higher mortality rate (4
Most fatalities resulted from
Liver enzymes tended to increase within the first 3 weeks of therapy and return to baseline with continued treatment