Phenytoin toxicity is rarely fatal, but can cause neurologic symptoms ranging from nystagmus to ataxia to coma
Hypersensitivity to phenytoin or other hydantoins is a contraindication for using phenytoin
Cross-sensitivity manifests frequently between phenytoin as the Dilantin sensitivity syndrome in 1950
Drug hypersensitivity syndrome is a specific, severe, unexpected reaction to a medicine, which affects several organ systems at the same time
The syndrome's main symptoms are cutaneous eruptions, fever, hepatitis, and lymphadenopathy
If there is a history of Dilantin hypersensitivity syndrome is characterized by fever, rash, lymphadenopathy, facial edema, and hepatitis, and the eruption may present as the classic erythematous follicular papules and pustules or as a morbilliform eruption, erythroderma, or toxic epidermal necrolysis
In this article, we present the clinical, laboratory and histopathologic results of 5 cases of PHS
ACHS is indicated by the presence of a triad of characteristic clinical features — fever, rash and internal organ involvement
The main symptoms of cutaneous eruptions, hepatitis, lymphadenopathy, as well as other manifestations, are described and discussed
It involves primarily a widespread skin rash, fever, swollen lymph nodes, and characteristic blood abnormalities such as an abnormally high level of eosinophils, low number of The clinical manifestations of the phenytoin hypersensitivity syndrome are reviewed
Heart rate at each visit and consider altering therapy if heart rate is less than 60 bpm 4
Some A fatal case of Stevens-Johnson syndrome that followed therapy with diphenylhydantoin sodium (Dilantin) is presented and the pathological findings at autopsy are described and briefly discussed
Carbamazepine, phenytoin, allopurinol, and lamotrigine are frequently implicated
3, 8, 11, 13, 29, 57 With diverse clinical features and variable presentations, there We report a life-threatening case of phenytoin hypersensitivity syndrome, a rare reaction primarily characterized by fever, skin eruptions, lymphadenopathy, eosinophilia, and hepatotoxicity
We investigated 53 patients with clinical sensitivity to anticonvulsants by exposing their lymphocytes in vitro to drug metabolites generated by a murine hepatic microsomal system
Hypersensitivity syndrome (HSS) or drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported in patients taking anticonvulsant drugs, including phenytoin
Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity reaction
1, 2 Because of the similarities in clinical, histopathologic findings, risk factors, and drug causality, these two conditions are now considered severe variants of an Phenytoin sodium is an antiepileptic drug
1988, Journal of Oral and Maxillofacial Surgery Antiepileptic drug hypersensitivity syndrome (fever, rash, lymphadenopathy and multiorgan failure) is potentially life-threatening
Cross-sensitivity manifests frequently between phenytoin Phenytoin hypersensitivity syndrome (PHS) is a rare, and important entity characterized by rash, fever, lymphadenopathy, leukocytosis with atypical lymphocytes, eosinophilia and associated hepatitis
Later, it became clear that a similar reaction pattern was noted following other drugs as well
Its etiology has been linked with lymphocyte activation Drug-induced hypersensitivity syndrome is associated with phenytoin in most cases and was originally referred to as phenytoin hypersensitivity syndrome (De et al
18 to 9
Anticonvulsant hypersensitivity syndrome, a potentially fatal but rare reaction, manifests as rash, fever, tender lymphadenopathy, hepatitis, and eosinophilia
The syndrome has been reported with aromatic antiepileptic drugs (AEDS); such as phenytoin, carbamazepine
Describe the signs and symptoms of phenytoin toxicity
1592/phco
Drug-induced hypersensitivity syndrome (DIHS) is a severe reaction to medication that can cause serious problems in many different body systems
2 The syndrome was referred to as anticonvulsant hyper sensitivity syndrome (AHS) in 1988, after its occur rence was
Anticonvulsant Hypersensitivity Syndrome (AHS) is a drug-induced, multiorgan syndrome which is potentially fatal
It is now
Theories regarding etiology and treatment options are discussed
The clinical manifestations of the phenytoin hypersensitivity syndrome are reviewed
The anticonvulsant hypersensitivity syndrome is a rare complication that occurs with the use of antiepileptic medications
Hypersensitivity syndrome (HSS) or drug reaction with eosinophilia and systemic symptoms (DRESS) has been reported in patients taking anticonvulsant drugs, including have experienced this syndrome in the past (with phenytoin or other anticonvulsant drugs), patients who have a family history of this syndrome and immunosuppressed patients
The clinical manifestations of the phenytoin hypersensitivity syndrome are reviewed
Phenytoin was then known as a "nerve sedative," and the hyper sensitivity reaction, or "nirvanol sickness," resolved on discontinuation of the hydantoin
Abstract
Carbamazepine, phenytoin, allopurinol, and lamotrigine are frequently implicated
I was admitted to the Norwalk, CT hospital with a high fever
It is often characterized by fever, rash, lymphadenopathy, hepatitis, and laboratory abnormalities
The clinical presentation is heterogeneous, and the disease course is