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  • Acetazolamide Use in Severe Chronic Obstructive Pulmonary Disease
  • 3 mg
  • The management of patients with exacerbations of COPD is discussed
  • Avoid or Use Alternate Drug
  • d
  • 2023 Apr
  • Abstract
  • The mean (–SD) age of participants was 57–9
  • g

    [ 1] A meta-analysis was performed of clinical trials involving acetazolamide

    Reasons of acetazolamide (ACTZ) inefficacy in patients with severe

    In patients with COPD, the condition is called post-hypercapnic alkalosis

    1399-6576

    Acetazolamide is a non-selective carbonic anhydrase inhibitor that inhibits renal tubular reabsorption of bicarbonate, leading to urinary alkalisation and metabolic acidosis

    This generally includes an acute change in one or more of the following cardinal symptoms: Cough increases in frequency and severity

    Case Report

    Antibiotica zijn effectief bij de exacerbaties van COPD die gepaard gaan met een toename van de dyspneu en het opgeven van purulent sputum

    If left untreated, it can progress to dyspnea at rest, rales, cyanosis, and a

    ) Acetazolamide can temporarily cause carbonated drinks to taste unpleasant

    Reversal of metabolic alkalosis may facilitate weaning from mechanical ventilation of patients with COPD

    due to over-diuresis)(10)

    We tested this hypothesis in a randomized, placebo-controlled, double

    This review examines the literature and indications for acetazolamide use in patients with COPD dating back to its initial release 6 decades ago

    15, hypoxia) for 15 min

    The same phenomenon has also been described in severe asthma, community-acquired pneumonia and obesity

    20 mg The article talks about “can’t breath” and “won’t breath”, the idea is that using the acetazolamide will cause metabolic acidosis which will need to be corrected by hyperventilation and thus correct the “won’t breath” and decrease the pCO2

    Acetazolamide is preferable to prevent AMS while ascending, and dexamethasone generally should be reserved for treatment, usually as an adjunct to descent

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