Progesterone preterm birth

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  • What about the use of progesterone to treat
  • Typical
  • Abstract
  • 1056/NEJMoa035140
  • 99% with 3
  • The primary outcome was preterm birth at <37 weeks
  • Food and Drug Administration (FDA) said that progesterone shots should no longer be used to prevent preterm birth

    Vaginal progesterone and 17-OHPC both reduced birth before 34 weeks' gestation in high-risk singleton pregnancies

    Results: Midwifery-led care was underutilized by groups most at risk for preterm birth and was shown to be effective at maintaining low preterm birth rates

    Access ACOG’s Practice Advisory “ Updated Clinical Guidance for the Use of Progesterone Supplementation for the Prevention of Recurrent Preterm Birth

    The primary outcome, incidence of respiratory distress syndrome, was similar in both groups: 10

    Since PTB is a major cause of worldwide neonatal mortality and morbidity, its prevention is of high priority in obstetric care

    Background: Preterm birth is a major complication of pregnancy associated with perinatal mortality and morbidity

    Another standard method to prevent preterm birth is the use of progesterone supplementation

    1 However, because of issues that are related to access and side-effects, adherence to 17OHPC is not always ideal 2,3 and may impact its effectiveness adversely in the real world

    “ACOG recognizes that the PROLONG clinical trial evaluating 17p in patients with a history of a prior spontaneous singleton preterm Introduction to management and issues of preterm birth

    Evidence of benefit in reducing preterm birth before 34 weeks was more certain for vaginal progesterone, but there was no clear evidence that either vaginal progesterone or 17-OHPC was superior A consistent direction of benefit was noted for other birth and neonatal outcomes, including preterm birth before 28 weeks, preterm

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