15 Generally, the dosing interval for an antibiotic is three times the half-life—the dosing interval for linezolid is every 12 hours
Maximum plasma concentrations are reached approximately 1 to 2 hours after dosing, and the absolute bioavailability is approximately 100%
For patients with osteomyelitis due to trauma, the infecting agents include S aureus, coliform bacilli, and Pseudomonas aeruginosa
News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point Drugs & Diseases CME & Education Academy Video Decision Point In hospitalized patients who have aspirated and developed a lung abscess, antibiotic therapy should include coverage against S aureus and Enterobacter and Pseudomonas species
Meta-analyses, systematic reviews, and randomized trials suggest that linezolid has at least equivalent outcomes for skin and soft tissue infections (including MRSA infections) when compared with intravenous vancomycin The optimal dosing for these antibiotics when used as prophylaxis is unknown and may be lower than the
We first published guidance for antibiotic dosing in obese adults in 2017, in which we critically reviewed articles identified from a broad search strategy to develop dosing recommendations for 35 antimicrobials
Dose: 20 mg/kg/day PO/IV divided q12h x10-14 days; Info: incr
Taking antibiotics like linezolid (Zyvox) can sometimes cause diarrhea that is contagious and may cause a colon inflammation
Tigecycline also has reported activity in vitro
Severe: obtain culture from I&D; use IV abx--may convert to oral when stable/improved
Regardless, paediatric linezolid dosing recommendations may need to evolve as additional data on optimal dosing in adults become available
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It works by killing bacteria or preventing their growth
Infections due to vancomycin-resistant Enterococcus faecium (VRE), with or without concurrent bacteremia