Linezolid antibiotic medscape

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  • 6%) Vomiting (2-4
  • Food and Drug Administration (FDA) in 2000 and entered the
  • This antibiotic treats only bacterial infections
  • Zyvox is used to treat different
  • 600 mg IV/PO q24h
  • 10 mg/kg intravenously or oral‡ every 8 hours
  • Linezolid belongs to the family of medicines called antibiotics
  • Pneumonia, community-acquired: 600 mg PO/IV Q12H x 5 days
  • 15 Generally, the dosing interval for an antibiotic is three times the half-life—the dosing interval for linezolid is every 12 hours

    Maximum plasma concentrations are reached approximately 1 to 2 hours after dosing, and the absolute bioavailability is approximately 100%

    For patients with osteomyelitis due to trauma, the infecting agents include S aureus, coliform bacilli, and Pseudomonas aeruginosa

    News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point Drugs & Diseases CME & Education Academy Video Decision Point In hospitalized patients who have aspirated and developed a lung abscess, antibiotic therapy should include coverage against S aureus and Enterobacter and Pseudomonas species

    Meta-analyses, systematic reviews, and randomized trials suggest that linezolid has at least equivalent outcomes for skin and soft tissue infections (including MRSA infections) when compared with intravenous vancomycin The optimal dosing for these antibiotics when used as prophylaxis is unknown and may be lower than the

    We first published guidance for antibiotic dosing in obese adults in 2017, in which we critically reviewed articles identified from a broad search strategy to develop dosing recommendations for 35 antimicrobials

    Dose: 20 mg/kg/day PO/IV divided q12h x10-14 days; Info: incr

    Taking antibiotics like linezolid (Zyvox) can sometimes cause diarrhea that is contagious and may cause a colon inflammation

    Tigecycline also has reported activity in vitro

    Severe: obtain culture from I&D; use IV abx--may convert to oral when stable/improved

    Regardless, paediatric linezolid dosing recommendations may need to evolve as additional data on optimal dosing in adults become available

    2

    It works by killing bacteria or preventing their growth

    Infections due to vancomycin-resistant Enterococcus faecium (VRE), with or without concurrent bacteremia

    g

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  • Linezolid antibiotic medscape
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