A dose restriction exists for simvastatin 80 mg due to a higher risk of myopathy and possible rhabdomyolysis, especially within the first 12 months of use
The maximum daily dosage of simvastatin (Zocor) has been changed from 80 mg per day to 40 mg per day
There are also new contraindications and dose limitations for when simvastatin is taken with certain other medications, the FDA stated
Trial limitations include reliance on physician coding to define the presence of a significantly increased in midand high-dose females
Limitations of Use Simvastatin has not been studied in Fredrickson Types I and V dyslipidemias
7% to 16
With Michael Simon Johnson
High levels of LDL-C are linked to a higher risk of heart attack, stroke and Simvastatin 10 mg tablets can be sold to the public to reduce risk of first coronary event in individuals at moderate risk of coronary heart disease (approx
Hepatotoxicity: Persistent elevations in serum transaminases have been reported; upon dose reduction, drug interruption, or Many of the statin–drug interactions involve the CYP3A4/5 drug metabolizing systems as simvastatin, lovastatin and atorvastatin are metabolized predominantly through this pathway FDA (2011) FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of
1) • Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminase can occur
If simvastatin treatment is desired, limit the dose to <20 mg daily
1) • Recommended starting dose for patients at high risk of CHD is • Adolescents (10-17 years of age) with HeFH: starting dose is 10 mg/day; maximum recommended dose is 40 mg/day
As a result, the FDA recommends that most people avoid taking this dose of simvastatin
An alternative agent is recommended depending on the desired potency; refer to specific country guidelines
They work similarly to help lower cholesterol levels and lower the risk of heart-related health complications
Simvastatin 80 mg should not be started in new patients, including patients already taking lower doses of the drug
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1) •Recommended starting dose for patients at high risk of CHD is 40 mg/day
Extended-release: Not recommended
The labels of simvastatin, Vytorin and Simcor have all been changed to include dosing recommendations when these drugs are used with medicines that can increase the level of simvastatin in the body, thus increasing the risk FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury