Key takeaways: All antidepressants are similarly effective for treating
SSRIs are less cardiotoxic than many first-generation antidepressants, but there is still evidence that they inhibit sodium, calcium, and potassium ion channels at concentrations near therapeutic
4 Rationale: The selective serotonin uptake inhibitor (SSRI) fluoxetine has been shown to not only increase the extracellular concentrations of serotonin, but also dopamine and norepinephrine extracellular concentrations in rat prefrontal cortex
The psychiatric management of this patient is described after fluoxetine was discontinued
Five notable commonly prescribed atypical antidepressants are: Bupropion
Gastrointestinal upset (such as constipation, diarrhea, or nausea) Headache
He has stopped taking his fluoxetine because it has affected his sexual performance
Prozac (fluoxetine): Comes in 10 mg, 20 mg, and 40 mg capsules, Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an
It works by acting
Norepinephrine is thought to play a role in the body’s stress response and helps to regulate sleep, alertness, and blood pressure
They are often used as first-line pharmacotherapy for depression and numerous other psychiatric disorders due to their safety, efficacy, and tolerability
Tricyclic and related antidepressants block the re-uptake of both serotonin and noradrenaline, although to different extents
In addition to sertraline and paroxetine, the SSRI fluoxetine has been recommended as first-line treatment (off label) for patients with PTSD
Rather, it uniquely alters other brain chemicals like noradrenaline and dopamine
Monoamine oxidase inhibitors (MAOIs) are a separate class from other antidepressants, treating different forms of depression and other nervous system disorders such as panic disorder, social phobia, and depression with atypical features
Olanzapine/fluoxetine (trade name Symbyax, created by Eli Lilly and Company) is a fixed-dose combination medication containing olanzapine (Zyprexa), an atypical antipsychotic, and fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI)
You may become sedated or feel drowsy
Mirtazapine inhibits the central presynaptic alpha-2-adrenergic receptors, which causes an increased release of serotonin and norepinephrine