Chloroquine dosing retina recommendation

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  • Most authors concur that some screening for early
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  • use alternative or monitor ECG: combo may incr
  • However, most patients are routinely given 400 mg of HCQ daily (or 250 mg CQ)

    0 mg/kg real weight, which correlates better with risk than ideal weight

    Although no absolute safe dose was identified, the RCO recommends the daily dose of HCQ to be <5 mg/kg/day for <5 years as relatively safe for retinal toxicity

    We recommend a maximum daily HCQ use of ≤5

    This article forms a summary of the key components of the Hydroxychloroquine retinopathy was previously considered rare since it was typically diagnosed at an advanced stage with symptoms of central visual loss and visible fundoscopic changes, such as “bull’s eye” maculopathy, characterized by loss of retinal

    According to the recommendation by the American Academy of Ophthalmology, the most significant major risk factors for CQ and HCQ retinal toxicity are high dose and long duration of use

    Chloroquine retinopathy is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus

    Chloroquine is a medication used in the management and treatment of malaria and inflammatory diseases

    Chloroquine retinopathy appears to follow a similar, but more rapid course when compared to hydroxychloroquine retinopathy

    This is called an

    How- ever, recommendations on dosage and criteria for judging risk have been revised

    Although HCQ is one of the safest disease-modifying

    If the maximum daily dosage recommendations are followed, the likelihood of toxicity from chloroquine Prevalence

    The new age‐adjusted doses, with corresponding AUC values are reported in Table 1

    5% was identified in patients taking HCQ for greater than 5 years, rising to almost 20% after 20 years of The risk increases further with continued use of the drug

    Depending on the specific disease, patients may be treated with either a chronic maintenance or acute high-level dose of chloroquine

    1-3 In 2011, the American Academy of Ophthalmology (AAO) recommended an ideal body weight–based maximum daily dose for ophthalmic safety

    The chloroquine dose for children should be calculated on their body weight (5 mg chloroquine base/kg/week) and must not exceed the adult dose

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools

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