• Charge distribution analysis, FMO analysis, and HOMO – LUMO energies were
Meloxicam is a preferential inhibitor of cyclooxygenase-2 (COX-2)
Meloxicam (5), an NSAID in the enol-carboxamide class, was developed on the basis of its antiinflammatory activity and relative safety in animal models
Comment:Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) with analgesic
The structural and energetic properties of meloxicam and its complexes with carboxylic acids were characterized, including tautmerism and dissociation in aqueous
Like other regression models, QSAR regression models relate a set of "predictor" variables (X) to the potency of the response variable (Y), while classification QSAR models Understanding the structure-activity relationships (SARs) of small molecules is important for developing probes and novel therapeutic agents in chemical biology and drug discovery
Compounds 36 and 37 had a superior safety profile with an ulcer index of 2
Meloxicam sodium | C14H12N3NaO4S2 | CID 4051 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities The effect was superior to meloxicam, the reference anti-inflammatory drug, for the majority of the TZD derivatives
In subsequent screening in microsomal assays using human COX-1 and COX-2, we discovered that it possessed a selectivity profile for COX-2 superior to piroxicam and other marketed NSAIDs
Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti In this work, crystal structure prediction (CSP) calculations were used to guide the crystallization of three elusive polymorphic forms of meloxicam (MLX): II, III, and V
In summary, 1,3-benzothiazinone derivatives are unique scaffolds with anti-inflammatory activity and low toxicity
Different factors have been
In the present work, we report the development of a molecular docking protocol based on AutoDock4 Zn for the search of new hCA VII inhibitors by virtual screening
49 µM and 36
A major challenge in the field of Gaucher disease has been the development of new therapeutic strategies including molecular chaperones
A robust and predictive QSAR model has been proven to be an efficient tool to predict 2 Implications of Structure-Activity Relationship