Apr 25, 2016 · A rough guide to making an adjustment to the daily dose that should increase a serum level without leading to supratherapeutic / toxic levels is: If the phenytoin concentration is < 7 mcg/mL, the dose may be increased by 100 mg/day
See more This updated formula uses an albumin coefficient of 0
The following equation is a simple pharmacokinetic equation to estimate a loading dose or resulting serum concentration
in therapeutic range? No, free
In advanced renal failure, there is reduced phenytoin binding to albumin and one will tend to underestimate free phenytoin levels
Phenytoin Level (mcg/mL) Albumin (g/dL) Select if Creatinine
45)
In patients with Creatinine Clearance < 20
Applies to the following strengths: 50 mg/mL; 50 mg; 100 mg; 30 mg; 25 mg/mL; 200 mg; 300 mg; sodium Usual Adult Dose for: Seizures Status Epilepticus
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Variation of total phenytoin, adjusted phenytoin, and free phenytoin with respect to plasma albumin concentration
There was a significant but weak–moderate correlation between measured and calculated free phenytoin concentration using conventional and revised
1
39), and 1
Purpose: In critically ill patients, monitoring free phenytoin concentration is a valuable method for phenytoin-dosage adjustment
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A target phenytoin concentration of 80µmol/L is, therefore, equivalent to 20mg/L
Conventional and revised Sheiner–Tozer
Phenytoin has significant albumin binding and when total phenytoin level is measured, it is assumed that the amount bound to albumin versus
7 L/kg is used
, concluded that not only drug therapy monitoring, drug dosage adjustment is important to the patients with hypoalbuminemia Introduction: We aimed to evaluate the pediatric fosphenytoin dosing regimen, including optimal timing for the measurement of total serum phenytoin concentration (C PHT)
PK, in particular, is a study of what the body does to a drug, deals with the processes of absorption, distribution, metabolism, and elimination (acronym ADME)
Use the advanced version if you wish to manipulate this value
A recommended daily maintenance dosage is usually 4 to 8 mg/kg/day in equally divided doses
Drug interactions Phenytoin interacts with numerous medications, which may affect the plasma concentration of phenytoin or the interacting drug
For phenytoin the salt correction factor is 0