Half-Life Elimination
Oral: Within 2 hours
PO (Adults): 20–80 mg/day as a single dose initially, may repeat in 6–8 hr; may ↑ dose by 20–40 mg every 6–8 hr until desired response
Peak serum concentrations of enalaprilat occur about 4 hours after an oral dose of enalapril
At recommended The effective half-life of enalaprilat following multiple doses of enalapril maleate is prolonged at this level of renal insufficiency In most patients studied, after oral administration of a single dose of enalapril, onset of antihypertensive activity was seen at one hour with peak reduction of blood pressure achieved by four to six hours
However, this drug is also widely used off-label to treat supraventricular tachyarrhythmias, such as atrial fibrillation, and to
S
This activity reviews the indications, contraindications, activity, adverse events
Plasma: Oral: 1 to 2 hours
Continuous IV infusion: Dilute 1 mg (5 mL) or 2 mg (10 mL) in 250 to 500 mL NS or D5W; typical final concentration 2 mcg/mL to 16 mcg/mL; also refer to institution-specific policies and procedures
Both enalapril and enalaprilat undergo renal excretion without further metabolism
04 mg)/mL oral suspension may be made with 49/51 mg tablets, Ora-Plus, and Ora-Sweet SF
Descriptions
The Food and Drug Administration (FDA) has approved furosemide to treat conditions with volume overload and edema secondary to congestive heart failure exacerbation, liver failure, or renal failure, including the nephrotic syndrome
Ascites, refractory (off-label use): Oral: 5 to 7
625 mg IV over 5 minutes; if the effect is not adequate after 1 hour, repeat the dose and administer 1