later studied it as the maximum dose for safety with methamphetamine
Some promising GABAergic medications include baclofen, tiagabine, and topiramate
Topiramate was shown to be effective for increasing cocaine abstinence, the proportion of cocaine nonuse days, and the proportion of patients to attain 3 consecutive
Aims: To assess the efficacy of topiramate in treating cocaine use disorder (i
Cocaine use disorder remains a serious problem in the USA and worldwide
Abstract: Background: cocaine craving is a core feature of cocaine use disorder and remains a critical challenge for abstinence and relapse prevention
The recommended total daily dose of TOPAMAX ® as adjunctive therapy in adults with partial onset seizures or Lennox-Gastaut Syndrome is 200 to 400 mg/day in
They may include paresthesias, impaired memory or concentration, mood changes, and sleepiness
Half of known abusers under 21 and most of 3,406 people arrested for drugs last year used cocaine
The subjects were randomly assigned to either a topiramate group (subjects received 50-200 mg of topiramate per day for 12 weeks) or a control group (subjects received placebo)
But topiramate may never receive approval for the treatment of addiction because of economic considerations
e
1 Cocaine use is associated with cardiovascular and neurologic effects, and chronic repeated exposure
urges—or craving—to use cocaine
, Mean topiramate dose was computed by summing the dose of all topiramate tablets that were ingested as registered in the medication file, divided by the total number of days that topiramate was taken
Topamax is said to help stop cravings, stabilize mood, and help prolong abstinence from drug or
Effects of the combination of metyrapone and oxazepam on cocaine
In clinical trials involving children ages 12 years and older who took Topamax for migraine, the most common side effects were: feeling of pins and needles or tingling
Similarly, studies have explored the use of Topamax in the treatment of cocaine dependence
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Patients were randomized to receive either topiramate (maximal daily dosage of 200 mg/day) or placebo and were administered an fMRI alcohol cue-reactivity task at baseline (before starting Cocaine, particularly in its base form ('crack'), has become one of the drugs of most concern in many countries, being associated with a wide range of medical, psychiatric and social problems for the individual, and with significant public order consequences for society [1–3]
It has emerged as an efficacious pharmacotherapeutic option for the treatment of addiction, especially alcohol use disorder (AUD)