Among antibiotics, those interfering with warfarin metabolism posed the greatest risk for an INR of 5
Interactions may increase the risk of internal bleeding
Please document antimicrobial drug-drug interactions in all pharmacy or medication management notes during the course of the interaction, including expected duration of
1–4 These conditions occur more frequently in older
10 Warfarin Interactions to Watch Out For
1345/aph
Find out more about BNF interactions information
Amoxicillin is an antibiotic that treats bacterial infections like pneumonia, bronchitis, and infections of
Severity: Severe
There are 638 drugs known to interact with warfarin, along with 8 disease interactions, and 5 alcohol/food interactions
A wealth of evidence from numerous studies consistently supports an elevated risk of serious bleeding in patients concurrently receiving antibiotics and warfarin therapy
Add a drug to Warfarin's hepatic metabolism and protein binding are the most common mechanisms for the occurrence of drug-drug interactions
Amoxicillin belongs to the group of medicines known as penicillin antibiotics
16,21 Thus, it is important to monitor INRs closely whenever antibiotics are initiated in the setting of chronic warfarin use
The anticoagulant effect of warfarin and other coumarins is reduced by rifamycins
Moderate warfarin food
Keflex (cephalexin) can be an effective treatment option for certain types of ear infections
Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein (P-gp) inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2
The following are key points to remember from this review article on select drug-drug interactions with direct oral anticoagulants (DOACs): DOACs, including apixaban, betrixaban, dabigatran, edoxaban, and rivaroxaban, offer many therapeutic advantages over warfarin and other vitamin K antagonists
The man was on warfarin [Coumadin] 7
When starting or changing these drugs, INRs should be monitored closely; decreased doses of warfarin may be required
Indeed, several case reports have been published of a purported interaction between azithromycin and warfarin
It can interact with some blood pressure medications, penicillin antibiotics, warfarin, and more
Depakote (divalproex) is an anti-seizure medication that treats seizures and bipolar disorder