Methotrexate and trimethoprim interaction

Impuesto de actos jurídicos documentados
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  • HEARD? About the risk of severe, potentially fatal, pancytopenia if
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  • A Steuer, J M Gumpel
  • Due to an additive antifolate effect, trimethoprim has been shown to rarely increase bone marrow suppression in patients receiving methotrexate

    EDITOR’S KEY POINTS

    A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole

    , Usman Sarwar

    Although MTX is generally well tolerated at low doses, serious and predictable organ toxicity, including myelosuppression, mucositis, hepatotoxicity, and kidney injury, can occur owing to drug interactions

    Trimethoprim increases the risk of haematological side-effects (sometimes fatal) when given with Methotrexate

    doi: 10

    There are 131 drugs known to interact with trimethoprim, along with 3 disease interactions

    Of the total drug

    Because trimethoprim-sulfamethoxazole (TMP-SMX) causes neutropenia in children with leukemia, we investigated the possibility that

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  • Methotrexate and trimethoprim interaction
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