Due to an additive antifolate effect, trimethoprim has been shown to rarely increase bone marrow suppression in patients receiving methotrexate
EDITOR’S KEY POINTS
A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole
, Usman Sarwar
Although MTX is generally well tolerated at low doses, serious and predictable organ toxicity, including myelosuppression, mucositis, hepatotoxicity, and kidney injury, can occur owing to drug interactions
Trimethoprim increases the risk of haematological side-effects (sometimes fatal) when given with Methotrexate
doi: 10
There are 131 drugs known to interact with trimethoprim, along with 3 disease interactions
Of the total drug
Because trimethoprim-sulfamethoxazole (TMP-SMX) causes neutropenia in children with leukemia, we investigated the possibility that